Development status: Active

Gram-positive activity

Propensity to select resistant bacteria Coumermycin resistant mutants could be selected in vitro in 15 S.aureus strains tested in

Combination therapy: Tested in combination with ciprofloxacin for the treatment of S.aures infections, no synergistic effect observed.

Mechanism of Action/Target pathogen: Inhibitor of topoismerase, tested for treatment of HIV-1 and MDR S.aureus infection

Reason dropped: Weak bacteriocidal activity at high concentration despite reasonable bacteriostatic activity at lower concentrations.

Additional information: Grunberg, E., R. Cleeland, and E. Titsworth. "Further observations on chemotherapeutic activity of coumermycin A1. I. Activity against Neisseria meningitidis type A and meningopneumonitis." Antimicrobial agents and chemotherapy 6 (1966): 397.