Highest development stage: Preclinical

Development dropped

Gram-positive activity

Mechanism of Action/Target pathogen: Potent DNA gyrase inhibitor with poor ability to penetrate cells.

Additional information: Goetschi E, Angehrn P, Gmuender H, et al. Cyclothialidine (Ro 09-1437) and its congeners; a new class of DNA gyrase inhibitors: synthesis and structure-activity relationships. 32nd-Intersci-Conf-Antimicrobial-Agents-Chemother 1992; 193