Highest development stage: Phase 2

Development dropped

Gram-negative activity

Mechanism of Action/Target pathogen: Cell Wall Inhibitor; Active against Clostridium difficile. Additionally in mice models of Staphyloccal septicaemia this was more effective than vancomycin.

Reason dropped: In a trial where animals were adminstered the body surface area extratrapolated doasege equivalent to the human dosage, there were some undesired side effects such as a significant increase in blood serum urea and also prolonged use at a high dosage revealed damaging side effects to kidneys and epithelium of the gastrointestinal tract which were reversible (1) But a derivative of chloroeremomycin was eventually developed as oritavancin (LS)