Highest development stage: Preclinical

Development status: Inactive

Gram-negative activity

Mechanism of Action/Target pathogen: Transglycosylase inhibitor; Inhibits VanA type VRE and MRSA

Reason dropped: This is likely to have been due to poor pharmokinetics (LS)

Additional information: Maki H, Miura K, Yamano Y, et al. Katanosin B and plusbacin A3: inhibitors of cell wall synthesis in methicillin-resistant Staphylococcus aureus. 39th-ICAAC 1999;329.