Development status: Experimental

Gram-negative activity

Propensity to select resistant bacteria N

Mechanism of Action/Target pathogen: Active against <i>Neisseria gonorrhoeae; </i>dual mode of action, causing inhibition of dihydrofolate reductase and disrupting integrity of the cytoplasmic membrane

Additional information: Synthetic compound; a pyrroloquinazolinediamine core with a biphenyl group - derivative of SCH-79797 (improved activity); mammalian cell cytotoxicity only observed at 100-1000x concentration to kill bacteria