Development status: Experimental

Gram-negative activity

Propensity to select resistant bacteria

Mechanism of Action/Target pathogen: Active against Acinetobacter baumannii including multidrug- and pan-resistant strains; perturbs lipoprotein trafficking through a mechanism involving LolE (contributes to shuttling proteins from inner to outer membrane)

Additional information: Synthetic compound from Drug Repurposing Hub molecules; machine learning-guided discovery