Development status: Experimental

Gram-negative activity

Mechanism of Action/Target pathogen: Inhibits <i>Escherichia coli </i>FtsZ polymerization

Additional information: Synthetic compound from TAXIS Pharmaceuticals Inc (FtsZ-targeting molecules for Gram-positive FtsZ); compounds have lipophilic aromatic groups and halogens at the C-4 and C-5 positions of the oxazole ring which are necessary for Gram-negative activity; induced morphological changes in <i>Escherichia coli </i>and <i>Klebsiella pneumoniae </i>indicative of cell division inhibition