Development status: Approved, off-patent, discontinued in most countries

Gram-positive activity

Gram-negative activity

Mechanism of Action/Target pathogen: Sulphonamides are structural analogues of p-aminobenzoic acid and act as competitive inhibitors (and alternate substrates) of dihydropteroate synthase (DHPS) to block the synthesis of folic acid. Primarily bacteriostatic; rapid emergence of resistance.

Additional information: Synthetic sufanilamide derivative; short-acting (4-8 hours). Oral application.