Development status: Approved, off-patent, not available in most countries

Gram-positive activity

Gram-negative activity

Mechanism of Action/Target pathogen: Inhibits protein synthesis by binding reversibly to the bacterial 30S ribosomal subunit and preventing the aminoacyl tRNA from binding to the A site of the ribosome. Wide spectrum including protozoae, e.g. Plasmodium

Additional information: Semisynthetic tetracycline derivative. Used for topical treatment of acne vulgaris.