Development status: Inactive

Gram-positive activity

Gram-negative activity

Mechanism of Action/Target pathogen: Inhibits protein synthesis by binding reversibly to the bacterial 30S ribosomal subunit and preventing the aminoacyl tRNA from binding to the A site of the ribosome. Wide spectrum including protozoae, e.g. Plasmodium

Additional information: Natural product produced by streptomyces. Hardly active against bacteria. Used for the therapy of hyponatremia and other non-infectious diseases.