Development status: Approved, off-patent

Gram-positive activity

Gram-negative activity

Mechanism of Action/Target pathogen: Inhibits protein synthesis by binding reversibly to the bacterial 30S ribosomal subunit and preventing the aminoacyl tRNA from binding to the A site of the ribosome. Active against Gram-positive bacteria and some Gram-negative bacteria (e.g. E. coli, Klebsiella, Acinetobacter)

Additional information: Semisynthetic minocycline derivative