Development status: Approved, withdrawn in most countries

Gram-positive activity

Mechanism of Action/Target pathogen: Binds to the peptidyl transferase component of the 50S subunit of ribosomes, thus inhibiting peptide bond formation and bacterial protein synthesis. It is active against Gram-positive bacteria.

Reason dropped: Reversible visual disturbance, syncope, exacerbation of myasthenia gravis and hepatic failure

Additional information: Semisynthetic macrolide