Development status: Inactive

Gram-positive activity

Gram-negative activity

Mechanism of Action/Target pathogen: Binds to the 23S rRNA of the 50S ribosomal subunit and inhibits the peptidyl transferase activity of the bacterial ribosome, thus preventing protein chain elongation. It is active against Gram-positive and Gram-negative bacteria.

Reason dropped: Strong inhibitor of mitochondrial protein synthesis

Additional information: Synthetic fluorinated derivative of thiamphenicol. Used in veterinary medicine