AntibioticDB

Development status: Experimental

Gram-positive activity

Mechanism of Action/Target pathogen: Inhibits the function of elongation factor G (EF-G), leading to the inhibition of protein synthesis. Bacteriostatic activity against Gram-positive bacteria

Additional information: Natural product produced by Aspergillus and other fungi

GtoPDB link: https://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=12329

Source: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2065532/

Citation (1): https://www.nature.com/articles/s41467-017-01813-9

Citation (2): https://pubs.acs.org/doi/10.1021/acs.jnatprod.8b00382

Citation (3): https://watermark.silverchair.com/evaa163.pdf?token=AQECAHi208BE49Ooan9kkhW_Ercy7Dm3ZL_9Cf3qfKAc485ysgAAAuEwggLdBgkqhkiG9w0BBwagggLOMIICygIBADCCAsMGCSqGSIb3DQEHATAeBglghkgBZQMEAS4wEQQMfOO3aKQlA6RjaO31AgEQgIIClOv_dSjvoI97m5UU3tBLtdpcdCN20QxXJ9uI36Nyi1r-cQU92YJJLJkDB7cFle0JVEmhH_e-u5By5dBDqwcwhMuI5UkJubwrbphUL_IZOnP-N2V6aWRpQUBRMvZ4fGJ8C93FCBojQ3wSmoO6B4zApuZN4HZbgSoTgdahzfCh37dFTwBwPCl3AcJNdOuTEWyNcCx7rlbgE6zxNh4QywlUaF7GtGivmC9h3OvttkQ65XUrMnu1Vy92xDC1KnJXkLwGzVre5uIheKaOj5Z1NYd-6n4R8T6sJRAB6RWjyMiOEGphgUKR6zfG4vadclnC2a0F-OAVG6CRs5Rr3Pd_EGp7RJTg38GVaifGWzB3F15HT3vxWjQ6ea5gcP6S4grTRz1iMY0mEthIp0yaVnQT2kj9goa27yIZ3-BefjoJUTq4-vZoG4CD9hyo7u0v5xDTNocLW1McZ8oPWstCj9m2d36MJT6OuhRRtnJJIKlC-r_OPHVNcp7B7walmt4j3NcRe2VNj7WCOjMrUI1dOgketUegKRcv9OqahBbybY3FKoJdXt0uxqTWmaofkXO3BJ73Obu6qS3kEJuGCzv3rYTGf_ary33r-c4h-GXyzog5FVCOqM_vI4aB0J5Chos3rpPTElYnKzq2CeX70PuUWZo1dwwD_Z34pVNtHtvYRba8JccuUdf835SNfTI5Nl_LIrrZ2hN32jjKXNKTgQaodE8C721hhIgzxK0c-PYXUoQ3kPwHZlWaQiuKC1d007o0g7o5WXT95xcVbf5JIEuEWNOpPA2alykyejE0XOJyfA4-XlQ4l8Qv9gu60VSkxuuOS-MXGTdX1JyPhxzSMTTeFB_eI01S22IW_IuWMx7wexdAO5nQEuBuhDTfpw

Compound/Drug Structure: https://pubchem.ncbi.nlm.nih.gov/compound/Helvolic-acid

Helvolic acid, fumigacin

Fusidane

1943