Development status: Approved, off-patent

Gram-positive activity

Gram-negative activity

Mechanism of Action/Target pathogen: Inhibits dihydrofolic acid reductase and thus, the synthesis of purine. Active against many Gram-psitive, Gram-negative strains, and protozoal pathogens

Additional information: Synthetic compound. Mostly used in fixed combination with sulfamethoxazole (synergistic combination) for treatment and prophylaxis. Oral and parenteral application.