AntibioticDB

Development status: Approved, off-patent

Gram-negative activity

Mechanism of Action/Target pathogen: Binds to bacterial penicillin-binding proteins (PBP) and interferes with bacterial cell wall integrity and synthesis. Active against Enterobacteriaceae incl. ESBL producers

Additional information: Prodrug of mecillinam. Used for oral therapy of urinary tract infections.

GtoPDB link: https://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=10922

Source: https://pubmed.ncbi.nlm.nih.gov/1157572/

Citation (1): https://watermark.silverchair.com/35.pdf?token=AQECAHi208BE49Ooan9kkhW_Ercy7Dm3ZL_9Cf3qfKAc485ysgAAAs4wggLKBgkqhkiG9w0BBwagggK7MIICtwIBADCCArAGCSqGSIb3DQEHATAeBglghkgBZQMEAS4wEQQMBR_wyaaqp2h3zAEvAgEQgIICgUC0BxOjTBjcZ-b41yGjrt74mU2HBKSpfWaQp1CvfefXgD6Fy7t9BtMIN2ofLLQQSCFQQcbmaTT185ILGP69fXhIkjFbcvIPtV5TJGA0ADAEw_SSQiyJbimp6XvQl0CE5Mf6ruv2IwwfdJSZ-J72odKCdBdl1SUu9Epw7f_j--PpNwq2uOsUIkt4XtSVIiyu36aTJkWkMyvx3bM-D5msTYHU2gaS6oj65ZZD99RI9acuYEM4M11Pq_ktiJzU_YoqzYVTAeLzrswIxBX2IsV5Xf78HkpL1C0MGoyqyd0dZ2RUBbM7nndm8i70utlMEONsb1jfPiINnk0X2udZBG8fxsCHW149nrqwsnuUzinui4sfvoyQYmgAcXiB7l73eFS8XCuEoRtcgfk8gcEU5AANkmwNYw_BnuZNZsA1HGxn_xJmRDniO5l5kJBuXr4QU_wjWsxyNVs-Bmh91lId-FSwal1eYv3UNLc8kL8nhonRxqHwJirRkcm5aeCb90GAqU1HFLgqRYuIozc2i9OB37fJG2S3WsfEP6YGrloLiCkGL5idZ-ApEA1h_bJ3zYKM2HbhlfA1antldhMnMecOd1hTuwKDib7mhk_bAUSKtNojklkb0OGZW5Ta4idHr7DOVCT_2VNyVe3FOahUtlwYxKreMoEF2TLHYIcMZYmu39T-nkGkIk1GCld5g1m_BnZIpVCnAgbZ9OXyt3YxLjrTrRmX7-RdQ59MPHsd0VYkxVQiCswtEoK3ZShVUDJl5bCkjDoxMEvJtHbNJFm0LbrwIiG3YOrGVk8Ribd-Tx66BERlymZ32Y0vOnLaKtjCIFb82dcZONLMviTh0XPwIoaR_vaNp4-X

Citation (2): https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9118732/

Citation (3): https://pubmed.ncbi.nlm.nih.gov/30518669/

Compound/Drug Structure: https://pubchem.ncbi.nlm.nih.gov/compound/115163

Pivmecillinam, amdinocillin pivoxil

Beta-lactam (penicillin)

1975