Development status: Approved, off-patent

Gram-positive activity

Mechanism of Action/Target pathogen: Binds to bacterial penicillin-binding proteins (PBP) and interferes with bacterial cell wall integrity and synthesis. Active against Gram-positive bacteria, especially staphylococci including penicillinase producing strains

Additional information: Semisynthetic penicillin, derived from 6-aminopenicillanic acid (6-APA). Parenteral application. It has replaced methicillin in clinical use