Development status: Approved, off-patent

Gram-positive activity

Mechanism of Action/Target pathogen: Stabilises peptidyl-tRNA in the pretranslocation complex, preventing translocation of the ribosome along the mRNA, and thus affecting bacterial protein synthesis. Active against Mycobacterium spp.

Additional information: Streptomyces natural product. Rarely used as alternative for multidrug resistant tuberculosis in combination; administered intravenously or in aerosol form.