Development status: Experimental

Gram-positive activity

Propensity to select resistant bacteria

Mechanism of Action/Target pathogen: Inhibits bacterial DNA gyrase via binding to the ATP-binding site of the GyrB subunit of the enzyme. Clorobiocin acts as competitive inhibitor of the ATPase reaction, very similar to novobiocin; active against staphylococci and little activity against E. coli

Additional information: Streptomyces natural product