AntibioticDB

Aztreonam + Avibactam

Drug combination: beta-lactam (monobactam) + beta-lactamase inhibitor (non-beta-lactam beta-lactamase inhibitor, diazabicyclooctane [DBO])

Pfizer Inc./Allergan PLC (formerly Actavis)

2012

Highest development stage: Phase 2
Development active
Gram-negative activity
Combination therapy
Mechanism of Action/Target pathogen: Metallo-β-lactamase-producing gram-negative organisms such as Enterobacteriaceae and Pseudomonas aeruginosa
GtoPDB link: https://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=10763
Citation (1): http://aac.asm.org/content/57/7/3299.full
Citation (2): https://aac.asm.org/content/61/9/e00472-17
Compound/Drug Structure: https://pubchem.ncbi.nlm.nih.gov/compound/5742832